BHLHE40 promotes macrophage pro-inflammatory gene expression and functions.

ABSTRACT: Macrophages are the principal innate immune cells that populate all major organs and provide the first line of cellular defense against infections and/or injuries. The immediate and early-responding macrophages must mount a robust pro-inflammatory response to protect the host by eliminating deleterious agents. The effective pro-inflammatory macrophage response requires the activation of complex transcriptional programs that modulate the dynamic regulation of inflammatory and metabolic gene expression. Therefore, transcription factors that govern pro-inflammatory and metabolic gene expression play an essential role in shaping the macrophage inflammatory response. Herein, we identify the basic helix-loop-helix family member e40 (BHLHE40), as a critical transcription factor that promotes broa

SUBMITTER: Zafar A 

PROVIDER: S-EPMC8607355 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature