Real-time sensing of neurotransmitters by functionalized nanopores embedded in a single live cell.

ABSTRACT: Interface between neuron cells and biomaterials is the key to real-time sensing, transmitting and manipulating of neuron activities, which are the long-term pursue of scientists and gain intense research focus recently. It is of great interest to develop a sensor with exquisite sensitivity and excellent selectivity for real-time monitoring neurotransmitters transport through single live cell. Sensing techniques including electrode-based methods, optogenetics, and nanowire cell penetration systems have been developed to monitor the neuron activities. However, their biocompatibilities remain a challenge. Protein nanopores with membrane compatibility and lumen tunability provide real-time, single-molecule sensitivities for biosensing of DNA, RNA, peptides and small molecules. In this study, a

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8607392 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature