Incidence of acute complications of herpes zoster among immunocompetent adults in England: a matched cohort study using routine health data.

ABSTRACT:

Background

Herpes zoster can cause rare but serious complications; the frequency of these complications has not been well described.

Objectives

To quantify the risks of acute non-postherpetic neuralgia (PHN) zoster complications, to inform vaccination policy.

Methods

We conducted a cohort study among unvaccinated immunocompetent adults with incident zoster, and age-, sex- and practice-matched control adults without zoster, using routinely collected health data from the UK Clinical Practice Research Datalink (years 2001 to 2018). Crude attributable risks of complications were estimated as the difference between Kaplan-Meier-estimated 3-month cumulative incidences in patients with zoster vs. controls. We used Cox models to obtain hazard ratios for our primary outcomes i

SUBMITTER: Forbes HJ 

PROVIDER: S-EPMC8607468 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature