Dissecting the Human Response to Staphylococcus aureus Systemic Infections.

ABSTRACT: Staphylococcus aureus is a common human commensal and the leading cause of diverse infections. To identify distinctive parameters associated with infection and colonization, we compared the immune and inflammatory responses of patients with a diagnosis of invasive S. aureus disease to healthy donors. We analyzed the inflammatory responses founding a pattern of distinctive cytokines significantly higher in the patients with invasive disease. The measure of antibody levels revealed a wide antibody responsiveness from all subjects to most of the antigens, with significantly higher response for some antigens in the invasive patients compared to control. Moreover, functional antibodies against toxins distinctively associated with the invasive disease. Finally, we examined the geno

SUBMITTER: Leuzzi R 

PROVIDER: S-EPMC8607524 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature