Individual non-esterified fatty acids and incident atrial fibrillation late in life.

ABSTRACT:

Objective

Obesity and dysmetabolism are major risk factors for atrial fibrillation (AF). Expansion of fat depots is associated with increased circulating total non-esterified fatty acids (NEFAs), elevated levels of which are associated with incident AF. We undertook comprehensive serum measurement of individual NEFA to identify specific associations with new-onset AF late in life.

Methods

The present study focused on participants with available serum and free of AF selected from the Cardiovascular Health Study, a community-based longitudinal investigation of older US adults. Thirty-five individual NEFAs were measured by gas chromatography. Cox regression was used to evaluate the association of individual NEFAs with incident AF.

Results

The study sample included 1872 p

SUBMITTER: Pellegrini CN 

PROVIDER: S-EPMC8607526 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature