STAT proteins: a kaleidoscope of canonical and non-canonical functions in immunity and cancer.

ABSTRACT: STAT proteins represent an important family of evolutionarily conserved transcription factors that play key roles in diverse biological processes, notably including blood and immune cell development and function. Classically, STAT proteins have been viewed as inducible activators of transcription that mediate cellular responses to extracellular signals, particularly cytokines. In this 'canonical' paradigm, latent STAT proteins become tyrosine phosphorylated following receptor activation, typically via downstream JAK proteins, facilitating their dimerization and translocation into the nucleus where they bind to specific sequences in the regulatory region of target genes to activate transcription. However, growing evidence has challenged this paradigm and identified alternate 'non-canonical'

SUBMITTER: Awasthi N 

PROVIDER: S-EPMC8607625 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature