Distinct associations of NEDD4L expression with genetic abnormalities and prognosis in acute myeloid leukemia.

ABSTRACT:

Background

There is mounting evidence that demonstrated the association of aberrant NEDD4L expression with diverse human cancers. However, the expression pattern and clinical implication of NEDD4L in acute myeloid leukemia (AML) remains poorly defined.

Methods

We systemically determined NEDD4L expression with its clinical significance in AML by both public data and our research cohort. Moreover, biological functions of NEDD4L in leukemogenesis were further tested by in vitro experiments.

Results

By the public data, we identified that low NEDD4L expression was correlated with AML among diverse human cancers. Expression of NEDD4L was remarkably decreased in AML compared with controls, and was confirmed by our research cohort. Clinically, low expression of NEDD4L was cor

SUBMITTER: Chu MQ 

PROVIDER: S-EPMC8607698 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature