Ontology highlight
ABSTRACT:
SUBMITTER: Koczor CA
PROVIDER: S-EPMC8607749 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Koczor Christopher A CA Saville Kate M KM Andrews Joel F JF Clark Jennifer J Fang Qingming Q Li Jianfeng J Al-Rahahleh Rasha Q RQ Ibrahim Md M McClellan Steven S Makarov Mikhail V MV Migaud Marie E ME Sobol Robert W RW
Cell reports 20211101 5
Assembly and disassembly of DNA repair protein complexes at DNA damage sites are essential for maintaining genomic integrity. Investigating factors coordinating assembly of the base excision repair (BER) proteins DNA polymerase β (Polβ) and XRCC1 to DNA lesion sites identifies a role for Polβ in regulating XRCC1 disassembly from DNA repair complexes and, conversely, demonstrates Polβ's dependence on XRCC1 for complex assembly. LivePAR, a genetically encoded probe for live-cell imaging of poly(AD ...[more]