Memory and naive gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy.

ABSTRACT:

Background

Peanut oral immunotherapy (POIT) has provided desensitization to peanut allergic individuals. Limited immunological evaluation exists during the first 24-weeks of POIT.

Objective

Regulatory T-cells (Tregs) are antigen induced immunosuppressive T-cells important in establishing tolerance. Delineation of early immunologic changes contributing to the development of peanut desensitization would help clarify the mechanism of action in POIT. We performed single-cell RNA sequencing (scRNAseq) on Tregs in pediatric subjects undergoing POIT during the first 24-weeks of therapy to evaluate early immunological changes induced by POIT.

Methods

PBMC samples from peanut allergic subjects between 5 and 12 years of age enrolled in a Phase 1/2a POIT study were collected and

SUBMITTER: Anvari S 

PROVIDER: S-EPMC8607808 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature