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Peer influence on obesity: Evidence from a natural experiment of a gene-environment interaction.

ABSTRACT: The role of peers in explaining the obesity epidemic is difficult to evaluate, largely due to selection (the tendency of similar individuals to make friends with each other). Our study addresses this selection issue by using data from a natural experiment of randomly assigned college roommates. We investigate whether and how peers, gender, and the FTO gene interactively influenced BMI. We find that women with a weight-prone version of the gene were about three pounds lighter if assigned frequently-exercising roommates than if assigned non-frequently-exercising roommates. However, living with frequently-exercising roommates had little impact for women without the weight-prone version of the gene or for men regardless of genotype. We find that individuals with the weight-prone version of the gene exercised more often when assigned frequently-exercising roommates. This might be a mechanism through which the effect of frequently-exercising roommates worked.

SUBMITTER: Li Y

PROVIDER: S-EPMC8607809 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Peer influence on obesity: Evidence from a natural experiment of a gene-environment interaction.

Li Yi Y Guo Guang G

Social science research 20201020

The role of peers in explaining the obesity epidemic is difficult to evaluate, largely due to selection (the tendency of similar individuals to make friends with each other). Our study addresses this selection issue by using data from a natural experiment of randomly assigned college roommates. We investigate whether and how peers, gender, and the FTO gene interactively influenced BMI. We find that women with a weight-prone version of the gene were about three pounds lighter if assigned frequent ...[more]

PMID: 33308683

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Project description:Adolescent drinking is an important public health concern, one that is influenced by both genetic and environmental factors. The functional variant rs1229984 in alcohol dehydrogenase 1B (ADH1B) has been associated at a genome-wide level with alcohol use disorders in diverse adult populations. However, few data are available regarding whether this variant influences early drinking behaviors and whether social context moderates this effect. This study examines the interplay between rs1229984 and peer drinking in the development of adolescent drinking milestones.One thousand five hundred and fifty European and African American individuals who had a full drink of alcohol before age 18 were selected from a longitudinal study of youth as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Cox proportional hazards regression, with G × E product terms in the final models, was used to study 2 primary outcomes during adolescence: age of first intoxication and age of first DSM-5 alcohol use disorder symptom.The minor A allele of rs1229984 was associated with a protective effect for first intoxication (HR = 0.56, 95% CI 0.41 to 0.76) and first DSM-5 symptom (HR = 0.45, 95% CI 0.26 to 0.77) in the final models. Reporting that most or all best friends drink was associated with a hazardous effect for first intoxication (HR = 1.81, 95% CI 1.62 to 2.01) and first DSM-5 symptom (HR = 2.17, 95% 1.88 to 2.50) in the final models. Furthermore, there was a significant G × E interaction for first intoxication (p = 0.002) and first DSM-5 symptom (p = 0.01). Among individuals reporting none or few best friends drinking, the ADH1B variant had a protective effect for adolescent drinking milestones, but for those reporting most or all best friends drinking, this effect was greatly reduced.Our results suggest that the risk factor of best friends drinking attenuates the protective effect of a well-established ADH1B variant for 2 adolescent drinking behaviors. These findings illustrate the interplay between genetic and environmental factors in the development of drinking milestones during adolescence.

Project description:ImportancePeer deviance (PD) strongly predicts externalizing psychopathologic conditions but has not been previously assessable in population cohorts. We sought to develop such an index of PD and to clarify its effects on risk of drug abuse (DA).ObjectivesTo examine how strongly PD increases the risk of DA and whether this community-level liability indicator interacts with key DA risk factors at the individual and family levels.Design, setting, and participantsStudies of future DA registration in 1,401,698 Swedish probands born from January 1, 1970, through December 31, 1985, and their adolescent peers in approximately 9200 small community areas. Peer deviance was defined as the proportion of individuals born within 5 years of the proband living in the same small community when the proband was 15 years old who eventually were registered for DA.Main outcomes and measuresDrug abuse recorded in medical, legal, or pharmacy registry records.ResultsPeer deviance was associated with future DA in the proband, with rates of DA in older and male peers more strongly predictive than in younger or female peers. The predictive power of PD was only slightly attenuated by adding measures of community deprivation, collective efficacy, or family socioeconomic status. Probands whose parents were divorced were more sensitive to the pathogenic effects of high PD environments. A robust positive interaction was also seen between genetic risk of DA (indexed by rates of DA in first-, second-, and third-degree relatives) and PD exposure.Conclusions and relevanceWith sufficient data, PD can be measured in populations and strongly predicts DA. In a nationwide sample, risk factors at the level of the individual (genetic vulnerability), family (parental loss), and community (PD) contribute substantially to risk of DA. Individuals at elevated DA risk because of parental divorce or high genetic liability are more sensitive to the pathogenic effects of PD. Although the effect of our PD measure on DA liability cannot be explained by standard measures of community or family risk, we cannot, with available data, discriminate definitively between the effect of true peer effects and other unmeasured risk factors.

Dataset Information

Peer influence on obesity: Evidence from a natural experiment of a gene-environment interaction.

Publications

Peer influence on obesity: Evidence from a natural experiment of a gene-environment interaction.

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