Multiple Mutations in Exon-2 of Med-12 Identified in Uterine Leiomyomata.

ABSTRACT:

Background

Uterine leiomyomata (UL), commonly known as uterine fibroids, are benign smooth muscle tumors of the myometrium. They cause pelvic pain, abnormal uterine bleeding, and infertility in women of reproductive age. The ovarian hormone estrogen is the main stimulator for the fibroid growth. The etiology is not yet clearly understood; however, UL are believed to be monoclonal tumors arising from a common progenitor cell. Chromosomal cytogenetic abnormalities have been demonstrated in 40-50% of the fibroids. The most frequent tumor specific genetic alterations in UL were identified in exon-2 of Mediator Complex Subunit 12 (MED-12).

Methods

In the present study, twenty-two multiple fibroids were evaluated both from the same uterus and from different uteri, of four women, f

SUBMITTER: Firdaus R 

PROVIDER: S-EPMC8607871 | biostudies-literature | 2021 Jul-Sep

REPOSITORIES: biostudies-literature