Ontology highlight
ABSTRACT:
SUBMITTER: Anees A
PROVIDER: S-EPMC8607908 | biostudies-literature | 2021 Nov-Dec
REPOSITORIES: biostudies-literature
Anees Amber A Salapa Hannah E HE Thibault Patricia A PA Hutchinson Catherine C Hammond S Austin SA Levin Michael C MC
eNeuro 20211118 6
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is an RNA binding protein (RBP) that is localized within neurons and plays crucial roles in RNA metabolism. Its importance in neuronal functioning is underscored from the study of its pathogenic features in many neurodegenerative diseases where neuronal hnRNP A1 is mislocalized from the nucleus to the cytoplasm resulting in loss of hnRNP A1 function. Here, we model hnRNP A1 loss-of-function by siRNA-mediated knock-down in differentiated Neuro ...[more]