Analysis of core genes for colorectal cancer prognosis based on immune and stromal scores.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the most common malignancies.An early diagnosis and an accurate prognosis are major focuses of CRC research. Tumor microenvironment cells and the extent of infiltrating immune and stromal cells contribute significantly to the tumor prognosis.

Methods

Immune and stromal scores were calculated based on the ESTIMATE algorithm using the sample expression profile of the The Cancer Genome Atlas (TCGA) database. GSE102479 was used as the validation database. Differentially expressed genes whose expression was significantly associated with the prognosis of CRC patients were identified based on the immune matrix score. Survival analysis was conducted on the union of the differentially expressed genes. A protein-protein interaction (PPI) ne

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC8607933 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature