Basophil activation test shows high accuracy in the diagnosis of peanut and tree nut allergy: The Markers of Nut Allergy Study.

ABSTRACT:

Background

Peanut and tree nut allergies are the most important causes of anaphylaxis. Co-reactivity to more than one nut is frequent, and co-sensitization in the absence of clinical data is often obtained. Confirmatory oral food challenges (OFCs) are inconsistently performed.

Objective

To investigate the utility of the basophil activation test (BAT) in diagnosing peanut and tree nut allergies.

Methods

The Markers Of Nut Allergy Study (MONAS) prospectively enrolled patients aged 0.5-17 years with confirmed peanut and/or tree nut (almond, cashew, hazelnut, pistachio, walnut) allergy or sensitization from Canadian (n = 150) and Austrian (n = 50) tertiary pediatric centers. BAT using %CD63⁺ basophils (SSClow/CCR3pos) as outcome was performed with whole blood s

SUBMITTER: Duan L 

PROVIDER: S-EPMC8608143 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature