Ontology highlight
ABSTRACT:
SUBMITTER: Bonanomi D
PROVIDER: S-EPMC8608148 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Bonanomi Dario D Valenza Fabiola F Chivatakarn Onanong O Sternfeld Matthew J MJ Driscoll Shawn P SP Aslanian Aaron A Lettieri Karen K Gullo Miriam M Badaloni Aurora A Lewcock Joseph W JW Hunter Tony T Pfaff Samuel L SL
Neuron 20190319 3
The rich functional diversity of the nervous system is founded in the specific connectivity of the underlying neural circuitry. Neurons are often preprogrammed to respond to multiple axon guidance signals because they use sequential guideposts along their pathways, but this necessitates a strict spatiotemporal regulation of intracellular signaling to ensure the cues are detected in the correct order. We performed a mouse mutagenesis screen and identified the Rho GTPase antagonist p190RhoGAP as a ...[more]