Multicellular spatial model of RNA virus replication and interferon responses reveals factors controlling plaque growth dynamics.

ABSTRACT: Respiratory viruses present major public health challenges, as evidenced by the 1918 Spanish Flu, the 1957 H2N2, 1968 H3N2, and 2009 H1N1 influenza pandemics, and the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Severe RNA virus respiratory infections often correlate with high viral load and excessive inflammation. Understanding the dynamics of the innate immune response and its manifestations at the cell and tissue levels is vital to understanding the mechanisms of immunopathology and to developing strain-independent treatments. Here, we present a novel spatialized multicellular computational model of RNA virus infection and the type-I interferon-mediated antiviral response that it induces within lung epithelial cells. The model is built using the CompuCe

SUBMITTER: Aponte-Serrano JO 

PROVIDER: S-EPMC8608315 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature