Greater radiologic evidence of hypothalamic gliosis predicts adiposity gain in children at risk for obesity.

ABSTRACT:

Objective

This study investigated, in a large pediatric population, whether magnetic resonance imaging (MRI) evidence of mediobasal hypothalamic (MBH) gliosis is associated with baseline or change over 1 year in body adiposity.

Methods

Cross-sectional and prospective cohort analyses were conducted within the Adolescent Brain Cognitive Development Study. Study 1 included 169 children with usable baseline T2-weighted MRI images and anthropometrics from baseline and 1-year follow-up study visits. Signal ratios compared T2 signal intensity in MBH and two reference regions (amygdala [AMY] and putamen) as a measure of MBH gliosis. Study 2 included a distinct group of 238 children with overweight or obesity to confirm initial findings in an independent sample.

Results

In Stu

SUBMITTER: Sewaybricker LE 

PROVIDER: S-EPMC8608399 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature