Risk of bias in observational studies using routinely collected data of comparative effectiveness research: a meta-research study.

ABSTRACT:

Background

To assess the completeness of reporting, research transparency practices, and risk of selection and immortal bias in observational studies using routinely collected data for comparative effectiveness research.

Method

We performed a meta-research study by searching PubMed for comparative effectiveness observational studies evaluating therapeutic interventions using routinely collected data published in high impact factor journals from 01/06/2018 to 30/06/2020. We assessed the reporting of the study design (i.e., eligibility, treatment assignment, and the start of follow-up). The risk of selection bias and immortal time bias was determined by assessing if the time of eligibility, the treatment assignment, and the start of follow-up were synchronized to mimic the ran

SUBMITTER: Nguyen VT 

PROVIDER: S-EPMC8608432 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature