Screening of Altered Metabolites and Metabolic Pathways in Celiac Disease Using NMR Spectroscopy.

ABSTRACT:

Background

Celiac disease (CeD) is an autoimmune intestinal disorder caused by gluten protein consumption in genetically predisposed individuals. As biopsy sampling is an invasive procedure, finding novel noninvasive serological markers for screening of at-risk CeD population is a priority. Metabolomics is helpful in monitoring metabolite changes in body fluids and tissues. In the present study, we evaluated serum metabolite levels of CeD patients relative to healthy controls with the aim of introducing new biomarkers for population screening.

Method

We compared the serum metabolic profile of CeD patients (n = 42) and healthy controls (n = 22) using NMR spectroscopy and multivariate analysis.

Result

25 metabolites were identified by serum metabolic profi

SUBMITTER: Khalkhal E 

PROVIDER: S-EPMC8608527 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature