Antibody conversion rates to SARS-CoV-2 in saliva from children attending summer schools in Barcelona, Spain.

ABSTRACT:

Background

Surveillance tools to estimate viral transmission dynamics in young populations are essential to guide recommendations for school opening and management during viral epidemics. Ideally, sensitive techniques are required to detect low viral load exposures among asymptomatic children. We aimed to estimate SARS-CoV-2 infection rates in children and adult populations in a school-like environment during the initial COVID-19 pandemic waves using an antibody-based field-deployable and non-invasive approach.

Methods

Saliva antibody conversion defined as ≥ 4-fold increase in IgM, IgA, and/or IgG levels to five SARS-CoV-2 antigens including spike and nucleocapsid constructs was evaluated in 1509 children and 396 adults by high-throughput Luminex assays in samples collected

SUBMITTER: Dobano C 

PROVIDER: S-EPMC8608564 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature