Pituitary Adenylate Cyclase Activating Polypeptide Inhibits A₁₀ Dopamine Neurons and Suppresses the Binge-like Consumption of Palatable Food.

ABSTRACT: Pituitary adenylate cyclase-activating polypeptide (PACAP) binds to PACAP-specific (PAC1) receptors in multiple hypothalamic areas, especially those regulating energy balance. PACAP neurons in the ventromedial nucleus (VMN) exert anorexigenic effects within the homeostatic energy balance circuitry. Since PACAP can also reduce the consumption of palatable food, we tested the hypothesis that VMN PACAP neurons project to the ventral tegmental area (VTA) to inhibit A₁₀ dopamine neurons via PAC1 receptors and K_ATP channels, and thereby suppress binge-like consumption. We performed electrophysiological recordings in mesencephalic slices from male PACAP-Cre and tyrosine hydroxylase (TH)-Cre mice. Initially, we injected PACAP (30 pmol) into the VTA, where it suppressed binge

SUBMITTER: Le N 

PROVIDER: S-EPMC8608708 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature