Identifying causality, genetic correlation, priority and pathways of large-scale complex exposures of breast and ovarian cancers.

ABSTRACT:

Background

Genetic correlations, causalities and pathways between large-scale complex exposures and ovarian and breast cancers need systematic exploration.

Methods

Mendelian randomisation (MR) and genetic correlation (GC) were used to identify causal biomarkers from 95 cancer-related exposures for risk of breast cancer [BC: oestrogen receptor-positive (ER + BC) and oestrogen receptor-negative (ER - BC) subtypes] and ovarian cancer [OC: high-grade serous (HGSOC), low-grade serous, invasive mucinous (IMOC), endometrioid (EOC) and clear cell (CCOC) subtypes].

Results

Of 31 identified robust risk factors, 16 were new causal biomarkers for BC and OC. Body mass index (BMI), body fat mass (BFM), comparative body size at age 10 (CBS-10), waist circumference (WC) and education

SUBMITTER: Si S 

PROVIDER: S-EPMC8608803 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature