Virus-based vaccine vectors with distinct replication mechanisms differentially infect and activate dendritic cells.

ABSTRACT: The precise mechanism by which many virus-based vectors activate immune responses remains unknown. Dendritic cells (DCs) play key roles in priming T cell responses and controlling virus replication, but their functions in generating protective immunity following vaccination with viral vectors are not always well understood. We hypothesized that highly immunogenic viral vectors with identical cell entry pathways but unique replication mechanisms differentially infect and activate DCs to promote antigen presentation and activation of distinctive antigen-specific T cell responses. To evaluate differences in replication mechanisms, we utilized a rhabdovirus vector (vesicular stomatitis virus; VSV) and an alphavirus-rhabdovirus hybrid vector (virus-like vesicles; VLV), which replicates like an

SUBMITTER: Chiale C 

PROVIDER: S-EPMC8608815 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature