The aetiology of extreme tall stature in a screened Finnish paediatric population.

ABSTRACT:

Background

Extremely tall children (defined as height SDS (HSDS) ≥+3) are frequently referred to specialized healthcare for diagnostic work-up. However, no systematic studies focusing on such children currently exist. We investigated the aetiology, clinical features, and auxological clues indicative of syndromic tall stature in extremely tall children subject to population-wide growth monitoring and screening rules.

Methods

Subjects with HSDS ≥+3 after three years of age born between 1990 and 2010 were identified from the Helsinki University Hospital district growth database. We comprehensively reviewed their medical records up to December 2020 and recorded underlying diagnoses, auxological data, and clinical features.

Findings

We identified 424 subjects (214 girls an

SUBMITTER: Karkinen J 

PROVIDER: S-EPMC8608868 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature