Brain structural associations with depression in a large early adolescent sample (the ABCD study®).

ABSTRACT:

Background

Depression is the leading cause of disability worldwide with > 50% of cases emerging before the age of 25 years. Large-scale neuroimaging studies in depression implicate robust structural brain differences in the disorder. However, most studies have been conducted in adults and therefore, the temporal origins of depression-related imaging features remain largely unknown. This has important implications for understanding aetiology and informing timings of potential intervention.

Methods

Here, we examine associations between brain structure (cortical metrics and white matter microstructural integrity) and depression ratings (from caregiver and child), in a large sample (N = 8634) of early adolescents (9 to 11 years old) from the US-based, Adolescent Brain and

SUBMITTER: Shen X 

PROVIDER: S-EPMC8608869 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature