Significant decrease in interval colorectal cancer incidence after implementing immunochemical testing in a multiple-round guaiac-based screening programme.

ABSTRACT:

Background and aims

We aimed to evaluate the effects of switching to faecal immunochemical testing (FIT) on the cumulative 2-year incidence rate of interval cancers, interval cancer rate and test sensitivity within a mature population-based colorectal cancer screening programme consisting of six rounds of biennial guaiac faecal occult blood testing (gFOBT).

Methods

The FIT results were compared with those of gFOBT used in each of the previous two rounds. For the three rounds analysed, 279,041 tests were performed by 156,186 individuals. Logistic regression analysis was used to determine interval cancer risk factors (Poisson regression) and to compare the sensitivity of FIT to gFOBT.

Results

There were 612 cases of screen-detected cancers and 209 cases of interval canc

SUBMITTER: Bretagne JF 

PROVIDER: S-EPMC8608916 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature