Ontology highlight
ABSTRACT:
SUBMITTER: Torres Diaz CV
PROVIDER: S-EPMC8608991 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Torres Diaz Cristina V CV González-Escamilla Gabriel G Ciolac Dumitru D Navas García Marta M Pulido Rivas Paloma P Sola Rafael G RG Barbosa Antonio A Pastor Jesús J Vega-Zelaya Lorena L Groppa Sergiu S
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20210426 3
Deep brain stimulation (DBS), specifically thalamic DBS, has achieved promising results to reduce seizure severity and frequency in pharmacoresistant epilepsies, thereby establishing it for clinical use. The mechanisms of action are, however, still unknown. We evidenced the brain networks directly modulated by centromedian (CM) nucleus-DBS and responsible for clinical outcomes in a cohort of patients uniquely diagnosed with generalized pharmacoresistant epilepsy. Preoperative imaging and long-te ...[more]