Autologous platelet-rich plasma treatment for moderate-severe Asherman syndrome: the first experience.

ABSTRACT:

Purpose

Treatment of Asherman syndrome (AS) presents a significant clinical challenge. Based on our in vitro data showing that PRP could activate endometrial cell proliferation and migration, we hypothesized that intrauterine infusion of autologous platelet-rich plasma (PRP) may improve endometrial regeneration and fertility outcomes in patients with moderate-severe AS.

Materials and methods

Subjects with moderate-severe AS were randomized to PRP or saline control administered following hysteroscopic adhesiolysis. Due to relative inability to randomize patients to the control group, after initial randomization of 10 subjects (6 in PRP and 4 in control groups), the remainder were prospectively enrolled in PRP group (n = 9), with 11 historic controls added to control group, fo

SUBMITTER: Aghajanova L 

PROVIDER: S-EPMC8609080 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature