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The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases.

ABSTRACT: YTHDF1 is the most versatile and powerful reader protein of N ⁶-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases.

SUBMITTER: Chen Z

PROVIDER: S-EPMC8609105 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases.

Chen Zuyao Z Zhong Xiaolin X Xia Min M Zhong Jing J

Molecular therapy. Nucleic acids 20211104

YTHDF1 is the most versatile and powerful reader protein of N 6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes ...[more]

PMID: 34853726

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