Lifetime burden of disease due to incident tuberculosis: a global reappraisal including post-tuberculosis sequelae.

ABSTRACT:

Background

Many individuals who survive tuberculosis disease face ongoing disability and elevated mortality risks. However, the impact of post-tuberculosis sequelae is generally omitted from policy analyses and disease burden estimates. We therefore estimated the global burden of tuberculosis, inclusive of post-tuberculosis morbidity and mortality.

Methods

We constructed a hypothetical cohort of individuals developing tuberculosis in 2019, including pulmonary and extrapulmonary disease. We simulated lifetime health outcomes for this cohort, stratified by country, age, sex, HIV status, and treatment status. We used disability-adjusted life-years (DALYs) to summarise fatal and non-fatal health losses attributable to tuberculosis, during the disease episode and afterwards. We e

SUBMITTER: Menzies NA 

PROVIDER: S-EPMC8609280 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature