Evaluation of Intensive vs Standard Blood Pressure Reduction and Association With Cognitive Decline and Dementia: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Optimal blood pressure (BP) targets for the prevention of cognitive impairment remain uncertain.

Objective

To explore the association of intensive (ie, lower than usual) BP reduction vs standard BP management with the incidence of cognitive decline and dementia in adults with hypertension.

Data sources and study selection

A systematic review and meta-analysis of randomized clinical trials that evaluated the association of intensive systolic BP lowering on cognitive outcomes by searching MEDLINE, Embase, CENTRAL, Web of Science, CINAHL, PsycINFO, the International Clinical Trials Registry Platform, and ClinicalTrials.gov from database inception to October 27, 2020.

Data extraction and synthesis

Data screening and extraction were performed independentl

SUBMITTER: Dallaire-Theroux C 

PROVIDER: S-EPMC8609411 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature