Anti-EpCAM functionalized graphene oxide vector for tumor targeted siRNA delivery and cancer therapy.

ABSTRACT: Graphene oxide (GO) has emerged as a potential drug delivery vector. For siRNA delivery, GO should be modified to endow it with gene delivery ability and targeting effect. However, the cationic materials used previously usually had greater toxicity. In this study, GO was modified with a non-toxicity cationic material (chitosan) and a tumor specific monoclonal antibody (anti-EpCAM) for the delivery of survivin-siRNA (GCE/siRNA). And the vector (GCE) prepared was proved with excellent biosafety and tumor targeting effect. The GCE exhibited superior performance in loading siRNA, maintained stability in different solutions and showed excellent protection effect for survivin-siRNA in vitro. The gene silencing results in vitro showed that the mRNA level and protein level were down-

SUBMITTER: Chen S 

PROVIDER: S-EPMC8609427 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature