Risk of severe COVID-19 and mortality in patients with established chronic liver disease: a nationwide matched cohort study.

ABSTRACT:

Background and aims

Some, but not all, prior studies have suggested that patients with chronic liver disease are at increased risk of contracting COVID-19 and developing more severe disease. However, nationwide data are lacking from well-phenotyped cohorts with liver histology and comparisons to matched general population controls.

Methods

We conducted a nationwide cohort study of all Swedish adults with chronic liver disease (CLD) confirmed by liver biopsy between 1966 and 2017 (n = 42,320), who were alive on February 1, 2020. CLD cases were matched to ≤ 5 population comparators by age, sex, calendar year and county (n = 182,147). Using Cox regression, we estimated multivariable-adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for COVID-19 hospitalization an

SUBMITTER: Simon TG 

PROVIDER: S-EPMC8609512 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature