Assessing Genetic Overlap and Causality Between Blood Plasma Proteins and Alzheimer's Disease.

ABSTRACT:

Background

Blood plasma proteins have been associated with Alzheimer's disease (AD), but understanding which proteins are on the causal pathway remains challenging.

Objective

Investigate the genetic overlap between candidate proteins and AD using polygenic risk scores (PRS) and interrogate their causal relationship using bi-directional Mendelian randomization (MR).

Methods

Following a literature review, 31 proteins were selected for PRS analysis. PRS were constructed for prioritized proteins with and without the apolipoprotein E region (APOE+/-PRS) and tested for association with AD status across three cohorts (n = 6,244). An AD PRS was also tested for association with protein levels in one cohort (n = 410). Proteins showing association with AD were taken forward for

SUBMITTER: Handy A 

PROVIDER: S-EPMC8609677 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature