Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons.

ABSTRACT:

Background

Inherited mutations in the LRRK2 protein are common causes of Parkinson's disease, but the mechanisms by which increased kinase activity of mutant LRRK2 leads to pathological events remain to be determined. In vitro assays (heterologous cell culture, phospho-protein mass spectrometry) suggest that several Rab proteins might be directly phosphorylated by LRRK2-G2019S. An in vivo screen of Rab expression in dopaminergic neurons in young adult Drosophila demonstrated a strong genetic interaction between LRRK2-G2019S and Rab10.

Objective

To determine if Rab10 is necessary for LRRK2-induced pathophysiological responses in the neurons that control movement, vision, circadian activity, and memory. These four systems were chosen because they are modulated by dopaminergic

SUBMITTER: Fellgett A 

PROVIDER: S-EPMC8609683 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature