Chronic Kidney Disease Associated with Worsening White Matter Disease and Ventricular Enlargement.

ABSTRACT:

Background

Chronic kidney disease (CKD), a growing public health issue in the elderly, is associated with increased risk of cognitive impairment.

Objective

To investigate the mechanisms through which CKD impacts brain health using longitudinal imaging.

Methods

We identified 97 participants (74 CKD and 23 non-CKD) from the BRINK (BRain IN Kidney Disease), a longitudinal study of CKD with two MRI scans (baseline and 3-year follow-up). We measured the associations between baseline and change in kidney disease biomarkers of estimated glomerular filtration rate (eGFR) and urinary albumin to creatinine ratio (UACR), considered a measure of microvascular inflammation, and imaging outcomes of cortical thickness and ventricular volume from structural MRI, white matter hyperint

SUBMITTER: Vemuri P 

PROVIDER: S-EPMC8609691 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature