Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts.

ABSTRACT:

Background

Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson's disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on lacking whether patients with GBA-associated PD differ in their risk of developing motor complications compared to the general PD population.

Objective

To evaluate the association of GBA carrier status with the development of LIDS and MFs from early PD.

Methods

Motor complications were recorded prospectively in 884 patients with PD from four longitudinal cohorts using part IV of the UPDRS or MDS-UPDRS. Subjects were followed for up to 11 years and the associations of GBA mutations with the development of motor complications were assessed using parametric

SUBMITTER: Maple-Grodem J 

PROVIDER: S-EPMC8609705 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature