Unhealthy Behaviours and Risk of Parkinson's Disease: A Mendelian Randomisation Study.

ABSTRACT:

Background

Tobacco smoking and alcohol intake have been identified in observational studies as potentially protective factors against developing Parkinson's disease (PD); the impact of body mass index (BMI) on PD risk is debated. Whether such epidemiological associations are causal remains unclear. Mendelian randomsation (MR) uses genetic variants to explore the effects of exposures on outcomes; potentially reducing bias from residual confounding and reverse causation.

Objective

Using MR, we examined relationships between PD risk and three unhealthy behaviours: tobacco smoking, alcohol intake, and higher BMI.

Methods

19,924 PD cases and 2,413,087 controls were included in the analysis. We performed genome-wide association studies to identify single nucleotide polymorp

SUBMITTER: Heilbron K 

PROVIDER: S-EPMC8609708 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature