Ibrutinib protects T cells in patients with CLL from proliferation-induced senescence.

ABSTRACT:

Background

The development of Bruton's tyrosine kinase inhibitors (BTKi) for the treatment of chronic lymphocytic leukaemia (CLL) has provided a highly effective and relatively non-toxic alternative to conventional chemotherapy. Some studies have shown that BTKi can also lead to improvements in T cell immunity in patients despite in vitro analyses suggesting an immunosuppressive effect of BTKi on T cell function.

Methods

In this study, we examined both the in vitro effect and long-term in vivo effect of two clinically available BTKi, ibrutinib and zanubrutinib. Additional in vitro assessments were undertaken for a third BTKi, acalabrutinib. Immune subset phenotyping, cytokine secretion, T cell degranulation and proliferation assays were performed on peripheral blood mononucl

SUBMITTER: Davis JE 

PROVIDER: S-EPMC8609739 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature