Genome-wide DNA methylation analysis of pulmonary function in middle and old-aged Chinese monozygotic twins.

ABSTRACT:

Background

Previous studies have determined the epigenetic association between DNA methylation and pulmonary function among various ethnics, whereas this association is largely unknown in Chinese adults. Thus, we aimed to explore epigenetic relationships between genome-wide DNA methylation levels and pulmonary function among middle-aged Chinese monozygotic twins.

Methods

The monozygotic twin sample was drawn from the Qingdao Twin Registry. Pulmonary function was measured by three parameters including forced expiratory volume the first second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio. Linear mixed effect model was used to regress the methylation level of CpG sites on pulmonary function. After that, we applied Genomic Regions Enrichment of Annotations Tool (GREAT

SUBMITTER: Wang T 

PROVIDER: S-EPMC8609861 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature