Born to survive: how cancer cells resist CAR T cell therapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Lemoine J
PROVIDER: S-EPMC8609883 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Born to survive: how cancer cells resist CAR T cell therapy.
Lemoine Jean J Ruella Marco M Houot Roch R
Journal of hematology & oncology 20211122 1
Although chimeric antigen receptor T cells demonstrated remarkable efficacy in patients with chemo-resistant hematologic malignancies, a significant portion still resist or relapse. This immune evasion may be due to CAR T cells dysfunction, a hostile tumor microenvironment, or resistant cancer cells. Here, we review the intrinsic resistance mechanisms of cancer cells to CAR T cell therapy and potential strategies to circumvent them. ...[more]
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