The risk of atopic dermatitis may be affected by IL-1B +3954 C/T and IL-18 -137G/C polymorphisms: evidence from a meta-analysis.

ABSTRACT:

Introduction

Whether Th1-related cytokine polymorphisms influence the risk of atopic dermatitis (AD) remain inconclusive.

Aim

The authors performed a meta-analysis to robustly explore relationships between Th1-related cytokine polymorphisms and the risk of AD by merging the results of eligible publications.

Material and methods

The authors strictly adhere to the PRISMA guidelines in study design and implementation. A thorough literature search in Medline, Embase, Wanfang, VIP and CNKI was performed by the authors to identify eligible publications. Relationships between TNF-α/IL-1/IL-6/IL-18 polymorphisms and the risk of AD were estimated with odds ratio and its 95% confidence interval. The statistically significant p value was set at 0.05.

SUBMITTER: Han L 

PROVIDER: S-EPMC8610053 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature