Establishment of a tumor immune microenvironment-based molecular classification system of breast cancer for immunotherapy.

ABSTRACT: Antitumor immunotherapy can enable promising and durable responses following their clinical application. However, heterogeneity in the tumor immune microenvironment leads to differences in the individual response rates. In this study, we identified novel immune-related molecular subclasses of breast cancer using a non-negative matrix factorization analysis. We enrolled 4184 patients with breast cancer, including 1104 patients from The Cancer Genome Atlas as a training cohort and 3080 patients from another four independent datasets as validation cohorts. In the training cohort, 36.9% of patients who exhibited significantly higher immunocyte infiltration and enrichment of immune response-associated signatures were categorized into an immune class, which was confirmed by probing the expressio

SUBMITTER: Zheng X 

PROVIDER: S-EPMC8610112 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature