UBB⁺¹ reduces amyloid-β cytotoxicity by activation of autophagy in yeast.

ABSTRACT: UBB⁺¹ is a mutated version of ubiquitin B peptide caused by a transcriptional frameshift due to the RNA polymerase II "slippage". The accumulation of UBB⁺¹ has been linked to ubiquitin-proteasome system (UPS) dysfunction and neurodegeneration. Alzheimer's disease (AD) is defined as a progressive neurodegeneration and aggregation of amyloid-β peptides (Aβ) is a prominent neuropathological feature of AD. In our previous study, we found that yeast cells expressing UBB⁺¹ at lower level display an increased resistance to cellular stresses under conditions of chronological aging. In order to examine the molecular mechanisms behind, here we performed genome-wide transcriptional analyses and molecular/cellular biology assays. We found that low UBB⁺¹ expr

SUBMITTER: Chen X 

PROVIDER: S-EPMC8610117 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature