Integrated analysis of expression, prognostic value and immune infiltration of GSDMs in hepatocellular carcinoma.

ABSTRACT: Six Gasdermins (GSDM) family members participate in various biological processes especially pyroptosis, as well as in the initiation and development of many types of cancer. However, the systematic analysis of the GSDM family in hepatocellular carcinoma (HCC) is lacking. In this study, several bioinformatics databases were recruited to analyze the roles of the GSDMs in differential expression, prognostic correlation, functional enrichment exploration, immune modulation, genetic alterations, and methylated modification in patients with HCC. Consequently, the mRNA expression of all the six GSDMs was accordantly increased in HCC, while only the protein expressions of GSDMB, GSDMD, and GSDME were apparently increased in HCC tissue. The expression of all the GSDMs (except GSDMA) was significant

SUBMITTER: Hu K 

PROVIDER: S-EPMC8610125 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature