Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy.

ABSTRACT: Tauopathies are a group of progressive neurodegenerative disorders characterized by the presence of insoluble intracellular tau filaments in the brain. Evidence suggests that there is a tight connection between mitochondrial dysfunction and tauopathies, including Alzheimer's disease. However, whether mitochondrial dysfunction occurs prior to the detection of tau aggregates in tauopathies remains elusive. Here, we utilized transgenic nematodes expressing the full length of wild type tau in neuronal cells and monitored mitochondrial morphology alterations over time. Although tau-expressing nematodes did not accumulate detectable levels of tau aggregates during larval stages, they displayed increased mitochondrial damage and locomotion defects compared to the control worms. Chelating calcium

SUBMITTER: Palikaras K 

PROVIDER: S-EPMC8610126 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature