Polymorphisms in lncRNA MIR2052HG and susceptibility to breast cancer in Chinese population.

ABSTRACT:

Background

Published studies based on pharmacokinetics have explored the relationship between the lncRNA MIR2052HG and the prognosis of breast cancer (BC) resistance and recurrence. However, the underlying association of MIR2052HG SNPs with BC development remains unclear.

Methods

Combining bioinformatics and databases, SNPs (Single Nucleotide Polymorphisms) in the MIR2052HG gene were screened, and SNPs in the lncRNA MIR2052HG were selected for genotyping among 504 Chinese Han patients and 505 healthy controls, which were frequency-matched for age (±2 years). Logistic regression analysis was used to explore the association between MIR2052HG SNPs and the BC risk. Interactions between the MIR2052HG SNPs and reproductive factors were fur

SUBMITTER: Yang H 

PROVIDER: S-EPMC8610136 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature