Development of an immune-related signature for predicting survival outcome and immunotherapy response in osteosarcoma.

ABSTRACT: Osteosarcoma (OS) is the most common bone cancer, mainly diagnosed in children and adolescents. So far, no reliable molecular biomarkers have been identified to effectively evaluate OS prognosis and immune infiltration. Herein, we curated transcriptome profiles and clinical information from the publicly available OS cohorts to establish an immune-related prognostic signature. Besides, immunotherapeutic cohorts of urothelial cancer and melanoma patients were also employed to infer immunotherapy prediction roles of the identified signature. Lymphocytes infiltration, immune response-related pathways and signatures in the microenvironment were assessed according to distinct risk subgroups. Based on the univariate Cox analysis and further feature selection implemented by the LASSO regression mo

SUBMITTER: Wang Q 

PROVIDER: S-EPMC8610143 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature