Homeostatic scaling is driven by a translation-dependent degradation axis that recruits miRISC remodeling.

ABSTRACT: Homeostatic scaling in neurons has been attributed to the individual contribution of either translation or degradation; however, there remains limited insight toward understanding how the interplay between the two processes effectuates synaptic homeostasis. Here, we report that a codependence between protein synthesis and degradation mechanisms drives synaptic homeostasis, whereas abrogation of either prevents it. Coordination between the two processes is achieved through the formation of a tripartite complex between translation regulators, the 26S proteasome, and the miRNA-induced silencing complex (miRISC) components such as Argonaute, MOV10, and Trim32 on actively translating transcripts or polysomes. The components of this ternary complex directly interact with each other in an RNA-dep

SUBMITTER: Srinivasan B 

PROVIDER: S-EPMC8610276 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature