Human macrophage polarization in the response to Mycobacterium leprae genomic DNA.

ABSTRACT: Infection with Mycobacterium leprae, the causative organism of leprosy, is still endemic in numerous parts of the world including the southwestern United States. The broad variation of symptoms in the leprosy disease spectrum range from the milder tuberculoid leprosy (paucibacillary) to the more severe and disfiguring lepromatous leprosy (multibacillary). The established thinking in the health community is that host response, rather than M. leprae strain variation, is the reason for the range of disease severity. More recent discoveries suggest that macrophage polarization also plays a significant role in the spectrum of leprosy disease but to what degree it contributes is not fully established. In this study, we aimed to analyze if different strains of M. leprae elici

SUBMITTER: Marin A 

PROVIDER: S-EPMC8610329 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature